Huang Yuan-Yuan, Ye Nan, Peng Dang-Wei, Li Guang-Yuan, Zhang Xian-Sheng
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230011, China.
Department of Urology, Anhui Public Health Clinical Center, Hefei 230011, China.
Asian J Androl. 2025 Jan 1;27(1):129-134. doi: 10.4103/aja202447. Epub 2024 Aug 2.
Parameters of peripheral blood cell have been shown as the potential predictors of erectile dysfunction (ED). To investigate the clinical significance of hematological parameters for predicting the risk of rapid ejaculation, we established a rat copulatory model on the basis of ejaculation distribution theory. Blood samples from different ejaculatory groups were collected for peripheral blood cell counts and serum serotonin (5-HT) tests. Meanwhile, the relationship between hematological parameters and ejaculatory behaviors was assessed. Final analysis included 11 rapid ejaculators, 10 normal ejaculators, and 10 sluggish ejaculators whose complete data were available. The platelet (PLT) count in rapid ejaculators was significantly lower than that in normal and sluggish ejaculators, whereas the platelet distribution width (PDW) and mean platelet volume (MPV) were significantly greater in rapid ejaculators. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis showed that the PLT was an independent protective factor for rapid ejaculation. Meanwhile, rapid ejaculators were found to have the lowest serum 5-HT compared to normal and sluggish ejaculators ( P < 0.001). Furthermore, there was a positive correlation between the PLT and serum 5-HT ( r = 0.662, P < 0.001), indicating that the PLT could indirectly reflect the serum 5-HT concentration. In addition, we assessed the association between the PLT and ejaculatory parameters. There was a negative correlation between ejaculation frequency (EF) and the PLT ( r = -0.595, P < 0.001), whereas there was a positive correlation between ejaculation latency (EL) and the PLT ( r = 0.740, P < 0.001). This study indicated that the PLT might be a useful and convenient diagnostic marker for predicting the risk of rapid ejaculation.
外周血细胞参数已被证明是勃起功能障碍（ED）的潜在预测指标。为了研究血液学参数对预测早泄风险的临床意义，我们基于射精分布理论建立了大鼠交配模型。收集不同射精组的血样进行外周血细胞计数和血清5-羟色胺（5-HT）检测。同时，评估血液学参数与射精行为之间的关系。最终分析纳入了11例早泄者、10例正常射精者和10例射精迟缓者，他们的完整数据均可用。早泄者的血小板（PLT）计数显著低于正常射精者和射精迟缓者，而早泄者的血小板分布宽度（PDW）和平均血小板体积（MPV）显著更高。多因素逻辑回归分析和受试者工作特征（ROC）曲线分析表明，PLT是早泄的独立保护因素。同时，发现早泄者的血清5-HT水平低于正常射精者和射精迟缓者（P<0.001）。此外，PLT与血清5-HT之间存在正相关（r=0.662，P<0.001），表明PLT可间接反映血清5-HT浓度。此外，我们评估了PLT与射精参数之间的关联。射精频率（EF）与PLT之间存在负相关（r=-0.595，P<0.001），而射精潜伏期（EL）与PLT之间存在正相关（r=0.740，P<0.001）。本研究表明，PLT可能是预测早泄风险的一个有用且便捷的诊断标志物。
