Blondel B, Crainic R, Dufraisse G, Candréa A, Horaud F
Dev Biol Stand. 1985;60:337-42.
Several independently variable neutralization epitopes were identified on type 1 poliovirus by testing various field isolates with a panel of homotypic monoclonal antibodies. According to their distribution among viruses tested, neutralization epitopes were classified as strain-specific or variable (V) and cross-reacting or constant (K). Operational, relationship between different neutralization epitopes was analysed by selecting mutants resistant to neutralization with monoclonal antibodies from wild Mahoney and attenuated Sabin type 1 poliovirus. The results of this study and their implication in the characterization of poliovirus antigenic structure by neutralization epitope formulae is discussed.
通过用一组同型单克隆抗体检测各种现场分离株，在1型脊髓灰质炎病毒上鉴定出几个独立可变的中和表位。根据它们在测试病毒中的分布，中和表位被分类为菌株特异性或可变（V）以及交叉反应或恒定（K）。在操作上，通过从野生马奥尼和减毒的1型脊髓灰质炎病毒萨宾株中选择对单克隆抗体中和具有抗性的突变体，分析了不同中和表位之间的关系。本文讨论了这项研究的结果及其在通过中和表位公式表征脊髓灰质炎病毒抗原结构中的意义。
