Suppr超能文献

糖尿病大鼠的肠神经:血管活性肠肽增加而P物质未增加。

Enteric nerves in diabetic rats: increase in vasoactive intestinal polypeptide but not substance P.

作者信息

Belai A, Lincoln J, Milner P, Crowe R, Loesch A, Burnstock G

出版信息

Gastroenterology. 1985 Nov;89(5):967-76. doi: 10.1016/0016-5085(85)90195-7.

Abstract

The distribution of vasoactive intestinal polypeptide (VIP) and substance P-like immunoreactivities was studied by immunohistochemistry in the myenteric plexus and circular muscle layer of the ileum and proximal colon of rats 8 wk after induction of diabetes with streptozotocin. A consistent increase was observed in fluorescence intensity of VIP-like immunoreactivity in the nerve fibers, and intensely stained cell bodies were significantly more frequent in the myenteric plexus of the ileum (p less than 0.001) from diabetic animals. Some varicosities of VIP-like immunoreactive fibers in the myenteric plexus appeared to be enlarged. Vasoactive intestinal polypeptide-like immunoreactivity was increased and VIP-like immunoreactive nerves appeared thicker in the circular muscle layer of both diabetic ileum and proximal colon. The VIP levels were measured biochemically in tissue consisting of the smooth muscle layers and myenteric plexus. A significant increase in the VIP content per centimeter of intestine was found in both the ileum (p less than and proximal colon (p less than 0.01) from diabetic rats. In contrast, no apparent change in substance P innervation was observed immunohistochemically in the myenteric plexus and circular muscle layer of either diabetic ileum or proximal colon when compared with controls. The results are discussed in relation to the symptoms of autonomic neuropathy of the gut in diabetes.

摘要

用免疫组织化学方法研究了链脲佐菌素诱导糖尿病8周后大鼠回肠和近端结肠肌间神经丛及环肌层中血管活性肠肽(VIP)和P物质样免疫反应性的分布。糖尿病动物回肠肌间神经丛中,神经纤维中VIP样免疫反应性荧光强度持续增加,且强染色的细胞体明显增多(p<0.001)。肌间神经丛中一些VIP样免疫反应性纤维的膨体似乎增大。糖尿病回肠和近端结肠的环肌层中,血管活性肠肽样免疫反应性增加,VIP样免疫反应性神经似乎变粗。对由平滑肌层和肌间神经丛组成的组织进行生化测定VIP水平。糖尿病大鼠的回肠(p<0.01)和近端结肠(p<0.01)每厘米肠道的VIP含量均显著增加。相比之下,与对照组相比,糖尿病回肠或近端结肠的肌间神经丛和环肌层中,P物质神经支配未见明显免疫组织化学变化。结合糖尿病肠道自主神经病变的症状对结果进行了讨论。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验