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糖尿病大鼠的肠神经：含血管活性肠肽纤维神经病变的电子显微镜证据

Enteric nerves in diabetic rats: electron microscopic evidence for neuropathy of vasoactive intestinal polypeptide-containing fibres.

作者信息

Loesch A, Belai A, Lincoln J, Burnstock G

出版信息

Acta Neuropathol. 1986;70(2):161-8. doi: 10.1007/BF00691434.

DOI:10.1007/BF00691434
PMID:3739623
Abstract

Enteric nerves in the ileum of rats 8 weeks after streptozotocin-induction of diabetes were examined under the electron microscope before and after immunolabeling for vasoactive intestinal polypeptide (VIP). These studies have provided evidence of degenerative changes in the myenteric nerve fibres of diabetic rats, many of which were shown to contain VIP. It is suggested that VIP-ergic nerves in the gut may play a role in the development of gastrointestinal dysfunction in diabetes.

摘要

在对链脲佐菌素诱导糖尿病8周的大鼠回肠肠神经进行免疫标记血管活性肠肽（VIP）前后，用电子显微镜进行了检查。这些研究提供了糖尿病大鼠肌间神经纤维退行性变化的证据，其中许多被证明含有VIP。研究表明，肠道中含VIP的神经可能在糖尿病胃肠功能障碍的发生中起作用。

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Enteric nerves in diabetic rats: electron microscopic evidence for neuropathy of vasoactive intestinal polypeptide-containing fibres.糖尿病大鼠的肠神经：含血管活性肠肽纤维神经病变的电子显微镜证据
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引用本文的文献

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Effects of vitamin E deficiency on autonomic neuroeffector mechanisms in the rat caecum, vas deferens and urinary bladder.维生素E缺乏对大鼠盲肠、输精管和膀胱自主神经效应机制的影响。
J Physiol. 1995 Sep 15;487 ( Pt 3)(Pt 3):773-86. doi: 10.1113/jphysiol.1995.sp020917.
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Effect of streptozotocin-induced diabetes mellitus on release of vasoactive intestinal polypeptide from rodent small intestine.

本文引用的文献

1
Immunohistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat.使用抗亮氨酸脑啡肽抗体的免疫组织化学研究：对大鼠神经系统的初步观察。
Neuroscience. 1976 Aug;1(4):349-51. doi: 10.1016/0306-4522(76)90063-4.
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An ultrastructural study of nerve profiles in the myenteric plexus of the rabbit colon.兔结肠肌间神经丛神经形态的超微结构研究。
Neuroscience. 1982 Jan;7(1):295-305. doi: 10.1016/0306-4522(82)90167-1.
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[Ultrastructure of diabetic autonomic neuropathy of the gastrointestinal tract].
链脲佐菌素诱导的糖尿病对啮齿动物小肠血管活性肠肽释放的影响。
Dig Dis Sci. 1995 Apr;40(4):828-36. doi: 10.1007/BF02064987.
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Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system.帕金森病：对肠神经系统中含路易小体神经元的免疫组织化学研究
Acta Neuropathol. 1990;79(6):581-3. doi: 10.1007/BF00294234.
[糖尿病性胃肠道自主神经病变的超微结构]
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Myenteric plexus in streptozotocin-treated rats. Neurochemical and histochemical evidence for diabetic neuropathy in the gut.链脲佐菌素处理大鼠的肠肌丛。肠道糖尿病神经病变的神经化学和组织化学证据。
Gastroenterology. 1984 Apr;86(4):654-61.
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VIPergic innervation in the gastrointestinal tract of diabetic rats.糖尿病大鼠胃肠道中的血管活性肠肽能神经支配
Hiroshima J Med Sci. 1983 Dec;32(4):469-78.
6
Experimental diabetic autonomic neuropathy characterization in streptozotocin-diabetic Sprague-Dawley rats.链脲佐菌素诱导的糖尿病斯普拉格-道利大鼠实验性糖尿病自主神经病变的特征
Lab Invest. 1983 Nov;49(5):538-52.
7
Experimental diabetic autonomic neuropathy.实验性糖尿病自主神经病变
Am J Pathol. 1981 May;103(2):210-25.
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Autonomic neuropathy in the streptozotocin diabetic rat.链脲佐菌素诱导的糖尿病大鼠的自主神经病变
Can J Neurol Sci. 1980 May;7(2):135-42. doi: 10.1017/s0317167100023519.
9
Ultrastructural localization of four different neuropeptides within separate populations of p-type nerves in the guinea pig colon.豚鼠结肠中p型神经不同群体内四种不同神经肽的超微结构定位。
Gastroenterology. 1983 Nov;85(5):1094-104.
10
Localisation of substance P-like immunoreactivity in the intramural nerve plexuses of the guinea-pig stomach using immunofluorescence and immunoperoxidase techniques.运用免疫荧光和免疫过氧化物酶技术对豚鼠胃壁内神经丛中P物质样免疫反应性进行定位。
J Anat. 1982 Sep;135(Pt 2):319-32.