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多组分级联反应合成新型色烯并吡唑啉酮骨架。

A multicomponent cascade reaction for the synthesis of novel chromenopyranpyrazole scaffolds.

机构信息

Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamilnadu, India.

出版信息

Chem Commun (Camb). 2013 Dec 4;49(93):10947-9. doi: 10.1039/c3cc45502e.

DOI:10.1039/c3cc45502e
PMID:24129404
Abstract

A catalyst, solvent, work-up and column free synthesis of chromenopyranpyrazoles via multicomponent cascade reaction has been achieved with high stereoselectivity. This novel reaction creates two N-C, two C-C and one O-C bonds through a domino process for the construction of three new rings and three contiguous stereogenic centers.

摘要

通过多组分级联反应，实现了一种无催化剂、无溶剂、无需后处理和柱层析的色烯并吡唑的高立体选择性合成。该新反应通过多米诺过程构建三个新环和三个连续的手性中心，形成了两个 N-C、两个 C-C 和一个 O-C 键。

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