Jensen Megan E, Gibson Peter G, Collins Clare E, Wood Lisa G
1] Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, New South Wales, Australia [2] Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia.
Faculty of Health, School of Health Sciences, University of Newcastle, New South Wales, Australia.
Pediatr Res. 2014 Jan;75(1-1):93-8. doi: 10.1038/pr.2013.181. Epub 2013 Oct 15.
Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score and body composition were associated with respiratory function in asthmatic children.
In a cross-sectional study, male (n = 27; mean age: 11.9 y (SD: 2.3)) and female (n = 21; mean age: 13.6 y (SD: 2.2)) asthmatic children underwent clinical assessment.
BMI z-score was associated with forced expiratory volume in 1 s (FEV1; r = 0.458), forced vital capacity (FVC; r = 0.477), and total lung capacity (TLC; r = 0.451) in males only (P < 0.05). Total lean mass was associated with FEV1 (r = 0.655), FVC (r = 0.562), and TLC (r = 0.635) in males, as was thoracic lean mass (FEV1 (r = 0.573), FVC (r = 0.526), and TLC (r = 0.497); P < 0.05). TLC was associated with total (r = 0.522) and thoracic (r = 0.532) lean mass in females (P < 0.05). Fat mass was not associated with lung function in this group.
Lean mass, not fat mass, is associated with lung function in children with asthma. The positive association between BMI z-score and respiratory function in male children is driven by lean mass. Although body weight can be easily monitored in the clinical setting, body composition can provide important information. Future research exploring lean mass and lung function associations could inform future interventions.
哮喘儿童的身体成分与肺功能之间是否存在关联尚未得到研究。本研究旨在初步调查体重指数（BMI）z评分和身体成分是否与哮喘儿童的呼吸功能相关。
在一项横断面研究中，对男性（n = 27；平均年龄：11.9岁（标准差：2.3））和女性（n = 21；平均年龄：13.6岁（标准差：2.2））哮喘儿童进行了临床评估。
仅在男性中，BMI z评分与1秒用力呼气量（FEV1；r = 0.458）、用力肺活量（FVC；r = 0.477）和肺总量（TLC；r = 0.451）相关（P < 0.05）。男性的总瘦体重与FEV1（r = 0.655）、FVC（r = 0.562）和TLC（r = 0.635）相关，胸部瘦体重也与之相关（FEV1（r = 0.573）、FVC（r = 0.526）和TLC（r = 0.497）；P < 0.05）。女性的TLC与总瘦体重（r = 0.522）和胸部瘦体重（r = 0.532）相关（P < 0.05）。该组中脂肪量与肺功能无关。
瘦体重而非脂肪量与哮喘儿童的肺功能相关。男性儿童中BMI z评分与呼吸功能之间的正相关是由瘦体重驱动的。虽然在临床环境中体重易于监测，但身体成分可提供重要信息。未来探索瘦体重与肺功能关联的研究可为未来的干预措施提供依据。
