替普司特（一种非甾体类抗过敏药）的选定免疫学特性。
Selected immunologic properties of tiprinast, a non-steroidal antiallergy agent.
作者信息
Gillespie E, Dungan K W, Gomoll A W, Seidehamel R J
出版信息
Int J Immunopharmacol. 1985;7(5):655-60. doi: 10.1016/0192-0561(85)90149-3.
PMID:2412976
Abstract
Tiprinast [(3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]- pyrimidine-2-carboxylic acid] is a new antiallergy compound which shares many of the pharmacological actions of disodium cromoglycate (DSCG). Both compounds inhibit passive cutaneous anaphylaxis in the rat, histamine release from rat peritoneal mast cells and nasal constriction due to antigen in the rat. In all cases tiprinast is more potent than DSCG and also longer acting.
摘要
替普司特[（3,4-二氢-5-甲基-6-（2-甲基丙基）-4-氧代噻吩并[2,3-d]嘧啶-2-羧酸]是一种新型抗过敏化合物，具有许多色甘酸二钠（DSCG）的药理作用。这两种化合物均能抑制大鼠被动皮肤过敏反应、大鼠腹腔肥大细胞组胺释放以及大鼠因抗原引起的鼻收缩。在所有情况下，替普司特都比色甘酸二钠更有效，且作用时间更长。
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