Gustafsson L, Falk A, Haglund U, Myrvold H E
Int J Microcirc Clin Exp. 1985;4(2):183-90.
A hyperviscous state with red cell aggregation and increased plasma viscosity was induced in cats by intravenous infusion of high molecular weight dextran. A segment of the small intestine was isolated with intact vascular and nervous supply and placed in a plethysmograph for determination of the intestinal tissue volume and capillary filtration coefficient. The intestinal blood flow was measured by a drop recorder unit. Measurements of intestinal blood flow, flow resistance and capillary filtration coefficient were performed during normotension and regional hypotension before and after infusion of high molecular weight dextran. After infusion of high molecular weight dextran, there was a twofold increase of blood viscosity and a threefold increase of plasma viscosity. Erythrocyte sedimentation rate exceeded 100 mm/h. Intestinal blood flow decreased by 35% during normotension and by 45% during regional hypotension. Intestinal flow resistance increased by 45% during normotension and by 65% during hypotension. The capillary filtration coefficient was not affected by the dextran infusion. It is concluded that the intestinal hemodynamic effects of high molecular weight dextran are mainly dependent of the increased plasma viscosity and that the number of perfused capillaries is not reduced by obstructing red cell aggregates.
通过静脉输注高分子量右旋糖酐在猫身上诱导出一种伴有红细胞聚集和血浆粘度增加的高粘滞状态。分离一段具有完整血管和神经供应的小肠，将其置于体积描记器中以测定肠组织体积和毛细血管滤过系数。通过滴数记录装置测量肠血流量。在输注高分子量右旋糖酐之前和之后，在正常血压和局部低血压期间进行肠血流量、血流阻力和毛细血管滤过系数的测量。输注高分子量右旋糖酐后，血液粘度增加两倍，血浆粘度增加三倍。红细胞沉降率超过100毫米/小时。在正常血压期间肠血流量减少35%，在局部低血压期间减少45%。在正常血压期间肠血流阻力增加45%，在低血压期间增加65%。毛细血管滤过系数不受右旋糖酐输注的影响。得出的结论是，高分子量右旋糖酐对肠道血流动力学的影响主要取决于血浆粘度的增加，并且灌注的毛细血管数量不会因红细胞聚集体的阻塞而减少。
