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基于微阵列的病毒诊断和鉴定用动物病毒探针数据集(AVPDS)。

Animal Viruses Probe dataset (AVPDS) for microarray-based diagnosis and identification of viruses.

机构信息

Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, India,

出版信息

Curr Microbiol. 2014 Mar;68(3):301-4. doi: 10.1007/s00284-013-0477-4. Epub 2013 Oct 16.

Abstract

AVPDS (Animal Viruses Probe dataset) is a dataset of virus-specific and conserve oligonucleotides for identification and diagnosis of viruses infecting animals. The current dataset contain 20,619 virus specific probes for 833 viruses and their subtypes and 3,988 conserved probes for 146 viral genera. Dataset of virus specific probe has been divided into two fields namely virus name and probe sequence. Similarly conserved probes for virus genera table have genus, and subgroup within genus name and probe sequence. The subgroup within genus is artificially divided subgroups with no taxonomic significance and contains probes which identifies viruses in that specific subgroup of the genus. Using this dataset we have successfully diagnosed the first case of Newcastle disease virus in sheep and reported a mixed infection of Bovine viral diarrhea and Bovine herpesvirus in cattle. These dataset also contains probes which cross reacts across species experimentally though computationally they meet specifications. These probes have been marked. We hope that this dataset will be useful in microarray-based detection of viruses. The dataset can be accessed through the link https://dl.dropboxusercontent.com/u/94060831/avpds/HOME.html.

摘要

AVPDS(动物病毒探针数据集)是一个专门用于识别和诊断感染动物的病毒的病毒特异性和保守寡核苷酸数据集。该数据集目前包含针对 833 种病毒及其亚型的 20,619 个病毒特异性探针,以及针对 146 种病毒属的 3,988 个保守探针。病毒特异性探针数据集分为两个字段,即病毒名称和探针序列。类似地,针对病毒属的保守探针表包含属名、属内亚群名称和探针序列。属内亚群是人为划分的亚群,没有分类学意义,包含可识别该属特定亚群中病毒的探针。使用这个数据集,我们成功地诊断了绵羊的新城疫病毒首例病例,并报告了牛病毒性腹泻和牛疱疹病毒的混合感染。该数据集还包含在实验中跨物种交叉反应的探针,但在计算上符合规格。这些探针已被标记。我们希望这个数据集能在基于微阵列的病毒检测中发挥作用。该数据集可通过以下链接访问:https://dl.dropboxusercontent.com/u/94060831/avpds/HOME.html。

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