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[狂犬病疫苗接种后的良性神经系统意外。意外的临床和生物学方面]

[Benign neurologic accident following anti-rabies vaccination. Unforeseen clinical and biological aspects].

作者信息

Lery L, Gaillard L, Delphin D

出版信息

Arch Fr Pediatr. 1975 Jun-Jul;32(6):563-7.

PMID:241305
Abstract

A minor and benign encephalitogenic reactions was observed in the days following administration of suckling mouse brain anti-rabies vaccine. The syndrome appeared at the 18th day of the treatment, undertaken according to Gamet and Atanasiu's shortened treatment schedule. Recovery occured without sequellae after 5 days of corticosteroid therapy. Compared to the reports of the literature, the benignity of the central nervous system involvement was unexpected. Three immunological problems are stressed out: the presence of sheep anti-red blood cells antibodies after antirabies vaccines; the presence of antismooth muscle antibodies; a previous BCG vaccination one month before antirabies treatment might play an adjuvant participation.

摘要

在给予乳鼠脑狂犬病疫苗后的几天内观察到轻微的良性致脑炎反应。该综合征出现在按照加梅特和阿塔纳修缩短的治疗方案进行治疗的第18天。在进行5天的皮质类固醇治疗后康复且无后遗症。与文献报道相比,中枢神经系统受累的良性程度出人意料。强调了三个免疫学问题:狂犬病疫苗接种后存在绵羊抗红细胞抗体;存在抗平滑肌抗体;在狂犬病治疗前一个月进行的卡介苗接种可能起辅助作用。

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