Chan-Palay V, Allen Y S, Lang W, Haesler U, Polak J M
J Comp Neurol. 1985 Aug 22;238(4):382-9. doi: 10.1002/cne.902380403.
The frontal, parietal, and temporal cortices in normal human brains (Brodmann areas 10, 7a, 7b, and 21) are well endowed with numerous neurons, identifiable by immunoreactivity with antisera against the 36-amino acid brain peptide neuropeptide Y (NPY). These neurons with rare exception are small, intracortical, nonspiny neurons, 12-20 microns in somatic size, with long slender dendrites and exuberant axon plexuses exhibiting finely beaded varicosities. The cells are rarest in layers I and II, are found with frequency in the lower cortical layers (IV-VI) and in significant numbers in the subcortical white matter. Within the cortex the axonal plexuses of these peptide neurons rise straight up into the upper cortical layers or descend deep into the white matter. In layers I and II, numerous other lengthy axons, some possibly of extracortical afferent origin, run along the pial surface at right angles to the axial ones running perpendicular to the cortex. This endowment of peptide neurons and their processes forms a rich network in the cerebral cortex, relating with one another in complex fashion within palisades of terminals as well as with the other cortical neurons not labeled by these methods. It remains to be shown what functions these NPY neurons have individually and in their remarkable networks, and how they are altered in neurological disease.
正常人类大脑中的额叶、顶叶和颞叶皮质（布罗德曼区10、7a、7b和21）富含大量神经元，可通过用抗36个氨基酸的脑肽神经肽Y（NPY）的抗血清进行免疫反应来识别。这些神经元除极少数外，均为小型、皮质内、无棘神经元，胞体大小为12 - 20微米，有细长的树突和丰富的轴突丛，轴突丛上有细小的串珠状膨体。这些细胞在I层和II层中最为稀少，在皮质下层（IV - VI层）有一定频率分布，在皮质下白质中有大量分布。在皮质内，这些肽能神经元的轴突丛直接向上延伸至皮质上层或向下深入白质。在I层和II层中，许多其他长轴突，有些可能起源于皮质外传入神经，沿着软脑膜表面与垂直于皮质的轴向轴突成直角分布。这种肽能神经元及其突起的分布在大脑皮质中形成了一个丰富的网络，它们在终末栅栏内以复杂的方式相互联系，同时也与未被这些方法标记的其他皮质神经元相互联系。这些NPY神经元个体及其显著网络具有何种功能，以及它们在神经系统疾病中如何发生改变，仍有待进一步研究。
