McGuire P K, Hockfield S, Goldman-Rakic P S
Section of Neuroanatomy, Yale University School of Medicine, New Haven, Connecticut 06510.
J Comp Neurol. 1989 Oct 8;288(2):280-96. doi: 10.1002/cne.902880207.
The distribution of the monoclonal antibody Cat-301 was examined in the frontal and parietal cortex of macaque monkeys. In both regions the distribution was uniform within cytoarchitecturally defined areas (or subareas) but varied between them. In all areas, Cat-301 labeled the soma and proximal dendrites of a restricted population of neurons. In the frontal lobe, Cat-301-positive neurons were intensely immunoreactive and present in large numbers in the motor cortex (area 4), premotor cortex (area 6, excluding its lower ventral part), the supplementary motor area (SMA), and the caudal prefrontal cortex (areas 8a, 8b and 45). In the parietal lobe, large numbers of intensely immunoreactive neurons were evident in the post-central gyrus (areas 1 and 2), the superior parietal lobule (PE/5), and the dorsal bank (PEa), fundus (IPd), and deep half of the ventral bank (POa(i] of the intraparietal sulcus (IPS). Two major patterns of laminar distribution were evident. In motor, supplementary motor, premotor (excluding the lower part of its ventral division), and the caudal prefrontal cortex (Walker's areas 8a, 8b and 45), and throughout the parietal cortex (with the exception of area 3), Cat-301-positive neurons were concentrated in the lower part of layer III and in layer V. The laminar positions of labeled cells in these areas were remarkably constant, as were the proportions of labeled neurons that had pyramidal and nonpyramidal morphologies (means of 30.2% and 69.8%, respectively). In contrast, in prefrontal areas 9, 10, 11, 12, 13, 14, and 46, in the cingulate cortex (areas 23, 24 and 25), and in the lower part of the ventral premotor cortex, Cat-301-positive neurons were spread diffusely across layers II to VI and a mean of 3.6% of the labeled neurons were pyramidal while 96.4% were nonpyramidal. Area 3 was unique among frontal and parietal areas, in that the labeled neurons in this area were concentrated in layers IV and VI. The areas in the frontal lobe which were heavily labeled are thought to be involved in the control of somatic (areas 4 and 6) and ocular (areas 8 and 45) movements. Those in parietal cortex may be classified as areas with somatosensory functions (1, 2, PE/5, and PEa) and areas which may participate in the analysis of visual motion (Pandya and Seltzer's IPd and POa(i), which contain Maunsell and Van Essen's VIP). The parietal somatosensory areas are connected to frontal areas with somatic motor functions, while POa(i) is interconnected with the frontal eye fields (8a and 45).(ABSTRACT TRUNCATED AT 250 WORDS)
在猕猴的额叶和顶叶皮质中检测了单克隆抗体Cat-301的分布。在这两个区域中，其分布在细胞结构定义的区域（或亚区域）内是均匀的，但在不同区域之间有所不同。在所有区域中，Cat-301标记了有限数量神经元的胞体和近端树突。在额叶中，Cat-301阳性神经元具有强烈的免疫反应性，大量存在于运动皮质（4区）、运动前皮质（6区，不包括其腹侧下部）、辅助运动区（SMA）和尾侧前额叶皮质（8a、8b和45区）。在顶叶中，大量具有强烈免疫反应性的神经元出现在中央后回（1区和2区）、顶上小叶（PE/5）以及顶内沟（IPS）的背侧缘（PEa）、底部（IPd）和腹侧缘深部（POa(i)）。明显存在两种主要的层状分布模式。在运动区、辅助运动区、运动前区（不包括其腹侧部的下部）以及尾侧前额叶皮质（沃克8a、8b和45区），以及整个顶叶皮质（3区除外），Cat-301阳性神经元集中在III层下部和V层。这些区域中标记细胞的层位非常恒定，具有锥体细胞和非锥体细胞形态的标记神经元比例也很恒定（分别平均为30.2%和69.8%）。相比之下，在额叶9、10、11、12、13、14和46区、扣带回皮质（23、24和25区）以及腹侧运动前皮质下部，Cat-301阳性神经元在II至VI层中广泛分布，平均3.6%的标记神经元为锥体细胞，96.4%为非锥体细胞。3区在额叶和顶叶区域中是独特的，因为该区域的标记神经元集中在IV层和VI层。额叶中标记密集的区域被认为参与躯体（4区和6区）和眼球（8区和45区）运动的控制。顶叶皮质中的那些区域可分为具有躯体感觉功能的区域（1、2、PE/5和PEa）以及可能参与视觉运动分析的区域（潘迪亚和塞尔泽的IPd和POa(i)，包含芒塞尔和范埃森的VIP）。顶叶躯体感觉区与具有躯体运动功能的额叶区域相连，而POa(i)与额叶眼区（8a和45区）相互连接。（摘要截断于250字）
