通过芳基重氮盐与 N-芳基丙烯酰胺的可见光介导自由基反应合成 3,3-二取代的氧吲哚。
Synthesis of 3,3-disubstituted oxindoles by visible-light-mediated radical reactions of aryl diazonium salts with N-arylacrylamides.
机构信息
College of Chemistry and Chemical Engineering, Luoyang Normal University , Luoyang 471022, P. R. China.
出版信息
J Org Chem. 2013 Dec 6;78(23):12202-6. doi: 10.1021/jo401894b. Epub 2013 Nov 1.
PMID:24131145
Abstract
A mild and efficient visible-light-mediated diarylation of N-arylacrylamides with aryl diazonium salts under mild conditions has been developed. This method provides convenient access to a variety of useful 3,3-disubstituted oxindoles by constructing two C-C bonds in one step.
摘要
发展了一种温和条件下 N-芳基丙烯酰胺与芳基重氮盐的温和高效可见光促进的二芳基化反应。该方法通过一步构建两个 C-C 键，为合成各种有用的 3,3-二取代的氧化吲哚提供了一种简便的方法。
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