过氧二异丙苯引发的 N-芳基丙烯酰胺和异氰化物的自由基级联甲基化/环化反应。
A free-radical cascade methylation/cyclization of N-arylacrylamides and isocyanides with dicumyl peroxide.
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, Gansu 730000, P. R. China.
出版信息
Org Lett. 2014 Nov 7;16(21):5670-3. doi: 10.1021/ol502738a. Epub 2014 Oct 15.
PMID:25318059
Abstract
A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.
摘要
用过氧化二异丙苯作为甲基化试剂，实现了 N-芳基丙烯酰胺和异氰化物的自由基级联甲基化/环化，为各种甲基化 N-杂环如吲哚酮和菲啶的合成提供了一种方便、选择性的方法。
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