Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
KingMed Diagnostics Group, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.
J Hum Hypertens. 2014 May;28(5):288-91. doi: 10.1038/jhh.2013.94. Epub 2013 Oct 17.
Hypertension is one of the most important risk and modifiable factors for stroke. Crucial in managing the cerebrovascular damage caused by long-lasting and inadequately treated hypertension is not only lowering arterial blood pressure but also early predicting subtypes of hypertension-related stroke and applying more effective interventions. Accumulating evidence suggested that circulating microRNAs (miRNAs) could be developed as biomarkers for early recognition of the onset of a variety of diseases. The role of miRNAs has been extensively reviewed, involving cardiac hypertrophy, hypertensive heart failure, kidney failure and renal fibrosis. miRNA research in stroke is still in its infancy, although there are few literatures reviewing the role of miRNAs in the processes of hypertension-related stroke. This review summarizes current advances in miRNAs regulation of critical pathogenic process underlying hypertension, ischemic stroke and hemorrhagic stroke, and highlights the potential of using circulating miRNAs as noninvasive biomarkers for the early detection of hypertension-related stroke.
高血压是中风最重要的风险和可改变的因素之一。在管理由长期和治疗不当的高血压引起的脑血管损伤方面，关键不仅在于降低动脉血压，还在于早期预测与高血压相关的中风亚型，并采取更有效的干预措施。越来越多的证据表明，循环 microRNAs（miRNAs）可以作为各种疾病早期识别的生物标志物。miRNAs 的作用已被广泛研究，涉及心脏肥大、高血压性心力衰竭、肾衰竭和肾纤维化。miRNA 在中风中的研究仍处于起步阶段，尽管有一些文献综述了 miRNAs 在与高血压相关的中风过程中的作用。本文综述了 miRNAs 对高血压、缺血性中风和出血性中风关键致病过程的调控作用的最新进展，并强调了将循环 miRNAs 用作高血压相关中风早期检测的非侵入性生物标志物的潜力。
