Kassis Haifa, Shehadah Amjad, Chopp Michael, Zhang Zheng Gang
Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA.
Department of Physics, Oakland University, Rochester, MI 48309, USA.
Genes (Basel). 2017 Feb 27;8(3):89. doi: 10.3390/genes8030089.
While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.
尽管由于对疾病超急性期的干预，中风死亡率持续下降，但长期残疾和机构化已成为中风后的常见后遗症。因此，识别可用于改善中风幸存者神经功能恢复的新分子途径至关重要。表观遗传机制，如组蛋白的翻译后修饰和微小RNA，最近已成为中风后修复过程中观察到的增强可塑性的关键调节因子。在这篇综述中，我们重点介绍了中风恢复表观遗传学这一不断发展领域的最新进展。
