Schmidt C J, Lovenberg W
Neurosci Lett. 1985 Aug 16;59(1):9-14. doi: 10.1016/0304-3940(85)90207-1.
Dopamine (DA) has been suggested as the penultimate agent in the neurotoxic effects of methamphetamine on serotonergic neurons. DA increases the efflux of tritium from rat neostriatal slices preloaded with [3H]serotonin in a concentration-dependent manner. This serotonin (5-HT) release is inhibited by the same selective uptake blockers previously shown to protect serotonergic neurons from the neurotoxic effects of methamphetamine in vivo. The results indicate that the 5-HT uptake carrier transports DA into the serotonergic neuron by a heteroexchange process with 5-HT. This further suggests that the excessive DA release induced by methamphetamine in vivo could lead to the uptake of DA into serotonergic neurons.
多巴胺（DA）被认为是甲基苯丙胺对血清素能神经元产生神经毒性作用的倒数第二个介质。多巴胺以浓度依赖的方式增加预先用[3H]血清素加载的大鼠新纹状体切片中氚的外流。这种血清素（5-HT）释放受到先前显示能在体内保护血清素能神经元免受甲基苯丙胺神经毒性作用的相同选择性摄取阻滞剂的抑制。结果表明，5-HT摄取载体通过与5-HT的异质交换过程将多巴胺转运到血清素能神经元中。这进一步表明，甲基苯丙胺在体内诱导的过量多巴胺释放可能导致多巴胺被摄取到血清素能神经元中。
