交叉选择性钛（III）催化的偶姻反应。
The cross-selective titanium(III)-catalysed acyloin reaction.
作者信息
Feurer Markus, Frey Georg, Luu Hieu-Trinh, Kratzert Daniel, Streuff Jan
机构信息
Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104 Freiburg, Germany.
出版信息
Chem Commun (Camb). 2014 May 25;50(40):5370-2. doi: 10.1039/c3cc46894a. Epub 2013 Oct 18.
PMID:24136642
Abstract
A titanium(III)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to α-hydroxylated and α-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed.
摘要
本文描述了一种钛（III）催化的酮或亚胺与腈的分子间还原偶联反应，该反应可直接生成α-羟基化和α-氨基化酮。这种偶联反应具有交叉选择性，是经典的偶姻缩合反应的催化版本。本文还讨论了一种由首次密度泛函理论（DFT）计算支持的反应机理。
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