Obukhov S K
Zh Vopr Neirokhir Im N N Burdenko. 1985 Jul-Aug(4):43-7.
The level of specific alpha 1-globulin (S alpha 1-GB) and autoantibodies to it was measured by the immunoenzyme method in blood serum of 160 donors and 88 neurological patients. The S alpha 1-GB level was increased most frequently in blood serum of patients with glial brain tumors. In malignant glial tumors the increased serum S alpha 1-GB level was combined with a reduced level of autoantibodies to it. The work discusses the role of the suggested immunochemical tests and the mechanisms of the increase in the S alpha 1-GB level and decrease in the level of autoantibodies to this antigen.
采用免疫酶法检测了160名献血者和88名神经科患者血清中特异性α1球蛋白(Sα1-GB)水平及其自身抗体。胶质脑肿瘤患者血清中Sα1-GB水平升高最为常见。在恶性胶质肿瘤中,血清Sα1-GB水平升高与针对它的自身抗体水平降低相关。本文探讨了所建议的免疫化学检测的作用以及Sα1-GB水平升高和针对该抗原的自身抗体水平降低的机制。