Vainio E, Kalimo K, Viander M, Reunala T
Acta Derm Venereol. 1985;65(4):291-7.
IgA and IgG class antigliadin antibodies (AGA) were analysed with ELISA technique from serum samples of 30 dermatitis herpetiformis patients. Jejunal biopsies were performed to all patients before any treatment and high levels of IgA class AGA were found to be associated with subtotal villous atrophy. Fourteen patients started gluten-free diet (GFD) which caused a significant decrease in both IgA and IgG class AGA. The decrease of IgA AGA was faster than that of IgG AGA and IgA antibody levels fell to normal range during the GFD treatment in all but one patient. In contrast, 5 out of 8 patients followed on normal died showed increasing IgA AGA levels and all of them had a rise in IgG AGA. IgA and IgG class antibodies to cow's milk were also measured in these patients but in contrast to AGA the diets had no clearcut effect on these antibodies.
采用酶联免疫吸附测定（ELISA）技术，对30例疱疹样皮炎患者血清样本中的IgA和IgG类抗麦醇溶蛋白抗体（AGA）进行了分析。在进行任何治疗之前，对所有患者进行了空肠活检，发现高水平的IgA类AGA与绒毛萎缩不全有关。14例患者开始无麸质饮食（GFD），这导致IgA和IgG类AGA均显著下降。IgA AGA的下降速度比IgG AGA快，除1例患者外，所有患者在GFD治疗期间IgA抗体水平均降至正常范围。相比之下，8例继续正常饮食的死亡患者中有5例IgA AGA水平升高，且所有患者的IgG AGA均升高。还对这些患者的IgA和IgG类抗牛奶抗体进行了检测，但与AGA不同，饮食对这些抗体没有明显影响。
