Medical Service, VA Connecticut Healthcare System, West Haven, CT, USA.
Nephrol Dial Transplant. 2014 Jan;29(1):22-8. doi: 10.1093/ndt/gft083. Epub 2013 Oct 17.
Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and heart, effectively metabolizes catecholamines. It was discovered during the search to identify proteins secreted by the kidney that could help explain the high incidence of cardiovascular disease in patients with chronic kidney disease. Recent advances have led to more detailed knowledge of its biology, structure, enzymatic activity, mechanisms of action, associations with human disease states and potential therapeutic value. In this study, we review these advances with a focus on hypertension and kidney disease.
肾酶，一种最近发现的黄素蛋白，在肾脏和心脏中表达强烈，能有效代谢儿茶酚胺。它是在寻找能帮助解释慢性肾脏病患者心血管疾病高发的肾脏分泌蛋白时被发现的。最近的研究进展使人们对其生物学、结构、酶活性、作用机制、与人类疾病状态的关联以及潜在的治疗价值有了更详细的了解。在这项研究中，我们重点关注高血压和肾脏疾病，对这些进展进行了综述。
