Serban-Feier Larisa Florina, Cuiban Elena, Gogosoiu Elena Bianca, Stepan Elena, Radulescu Daniela
Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Nephrology, Sfantul Ioan Clinical Emergency Hospital, 042122 Bucharest, Romania.
Biomedicines. 2024 Aug 1;12(8):1715. doi: 10.3390/biomedicines12081715.
Hypertension and cardiovascular disease are prominent features of chronic kidney disease, and they are associated with premature mortality and progression toward end-stage kidney disease. Renalase, an enzyme secreted predominantly by the kidney and identified in 2005, seems to be one of the missing pieces in the puzzle of heart and kidney interaction in chronic kidney disease by lowering blood pressure and reducing the overactivity of sympathetic tone. This review aims to summarize evidence from clinical studies performed on subjects with CKD in order to explore the value of renalase as a marker and/or a therapeutic target in this disease.
高血压和心血管疾病是慢性肾脏病的显著特征，它们与过早死亡以及进展至终末期肾病相关。肾酶是一种主要由肾脏分泌且于2005年被发现的酶，通过降低血压和减少交感神经张力的过度活跃，它似乎是慢性肾脏病中心脏与肾脏相互作用难题中缺失的环节之一。本综述旨在总结对慢性肾脏病患者进行的临床研究证据，以探讨肾酶作为该疾病标志物和/或治疗靶点的价值。
