一名患有IgM副蛋白血症和多神经根神经病患者体内的糖脂抗体。

Antibody to glycolipid in a patient with IgM paraproteinemia and polyradiculoneuropathy.

作者信息

Baba H, Miyatani N, Sato S, Yuasa T, Miyatake T

出版信息

Acta Neurol Scand. 1985 Aug;72(2):218-21. doi: 10.1111/j.1600-0404.1985.tb00867.x.

DOI:10.1111/j.1600-0404.1985.tb00867.x

Abstract

Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma reacted specifically with a lipid component in a crude ganglioside fraction isolated from human peripheral nerve, but did not react with myelin proteins including myelin-associated glycoprotein (MAG). The reactive glycolipid migrated between GM1 and GD1a gangliosides on TLC, and there was no distinct band corresponding to this glycolipid on examination with resorcinol reagent. Antibody to glycolipid in this case may play a role in the pathogenesis of neuropathy.

摘要

一名被诊断为恶性淋巴瘤的IgM副蛋白血症和多神经根神经病患者的血清，与从人周围神经分离出的粗神经节苷脂组分中的一种脂质成分发生特异性反应，但不与包括髓鞘相关糖蛋白（MAG）在内的髓鞘蛋白发生反应。该反应性糖脂在薄层层析（TLC）上迁移于GM1和GD1a神经节苷脂之间，用间苯二酚试剂检测时，没有与该糖脂相对应的明显条带。这种情况下针对糖脂的抗体可能在神经病变的发病机制中起作用。