Tanizaki Y, Komagoe H, Morinaga H, Ohtani J, Nakagawa S, Maeda M, Kitani H, Takahashi K, Kimura I
Acta Med Okayama. 1985 Aug;39(4):247-51. doi: 10.18926/AMO/31498.
The inhibitory effect of nicardipine, a calcium antagonist, on the antigen- and anti-IgE-induced histamine release from basophilic leucocytes of patients with bronchial asthma was examined. The agent significantly inhibited both antigen-stimulated and anti-IgE-induced histamine release from basophils (the maximum percent inhibition was 57.8 +/- 7.2% and 56.0 +/- 8.8%, respectively). Pre-incubation of basophils with nicardipine for periods of up to 120 min did not alter the inhibitory effect. These results suggest that nicardipine modifies the histamine release from basophils which closely participate in an attack of bronchial asthma.
研究了钙拮抗剂尼卡地平对支气管哮喘患者嗜碱性白细胞经抗原和抗IgE诱导的组胺释放的抑制作用。该药物显著抑制了嗜碱性粒细胞经抗原刺激和抗IgE诱导的组胺释放（最大抑制百分比分别为57.8±7.2%和56.0±8.8%）。嗜碱性粒细胞与尼卡地平预孵育长达120分钟并未改变其抑制作用。这些结果表明，尼卡地平可改变嗜碱性粒细胞的组胺释放，而嗜碱性粒细胞在支气管哮喘发作中密切参与。
