Wang Hai, Zhang Zhiyuan, Makki Mohammad Shahidul, Shi Qunli
Department of Pathology, Jinling Hospital, Nanjing University School of Medicine;
Oncol Lett. 2013 Aug;6(2):487-489. doi: 10.3892/ol.2013.1397. Epub 2013 Jun 14.
Myxopapillary ependymomas (MPEs) are uncommon and account for ∼15% of all ependymomas. The current study presents a case of rare spinal MPE with abnormal hyaline degeneration. The patient was a 72-year-old male with a 10-month history of lower back pain. Magnetic resonance imaging revealed a mass involving the L4 and L5 vertebrae with local bone destruction. The tumor was completely resected. Histologically, the majority of the tumor exhibited low cellularity. A marked change in hyaline was observed in the blood vessels and stroma. In specific areas, the tumor showed reticular or tubular patterning embedded in hyaline materials. The tumor cells were cuboidal to columnar in shape with strong immunostaining for glial fibrillary acidic protein and S-100. A fluorescence hybridization analysis for amplification of the epidermal growth factor receptor gene was negative. The results of pathological and immunohistochemical studies were consistent with the ependymal nature of neoplastic cells.
黏液乳头型室管膜瘤（MPEs）较为罕见，占所有室管膜瘤的15%左右。本研究报告了1例伴有异常透明变性的罕见脊髓MPE病例。患者为72岁男性，有10个月的下背部疼痛病史。磁共振成像显示一个累及L4和L5椎体的肿块，并伴有局部骨质破坏。肿瘤被完整切除。组织学检查显示，大部分肿瘤细胞密度较低。在血管和间质中观察到明显的透明样改变。在特定区域，肿瘤呈网状或管状结构，包埋于透明物质中。肿瘤细胞呈立方形至柱状，胶质纤维酸性蛋白和S-100免疫染色呈强阳性。表皮生长因子受体基因扩增的荧光杂交分析结果为阴性。病理和免疫组化研究结果与肿瘤细胞的室管膜性质相符。
