Zhao Jingjie, Zhang Xuedong, Liu Jianwei, Li Jianhua
Department of Pathology, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China.
Oncol Lett. 2013 Sep;6(3):745-747. doi: 10.3892/ol.2013.1446. Epub 2013 Jul 5.
The present study describes the case of a 77-year-old female with a recently self-detected, painless, 7-cm lump in the left breast, without evidence of metastasis clinically, who underwent mastectomy with dissection of the axillary lymph nodes. The tumor did not invade the chest wall and skin. The tumor was comprised of abundant chondroid matrix and fibrous tissue, with focal osteoid matrix, and was classified as a chondroblastic/fibroblastic variant. The tumor had a reverse zonal pattern. The tumor cells in the central portion were mainly spindle-like and sparse with minimal cytological atypia, while the remaining tumor cells in the periphery were mainly epithelioid, atypical and dense. Neoplastic osteoid woven bone or trabeculae were observed in the central portion of the tumor. No metastasis was identified in the axillary lymph nodes. The patient was alive without evidence of local recurrence or hematogenous spread at the 60-month follow-up.
本研究描述了一例77岁女性患者的病例，该患者近期自行发现左侧乳房有一个7厘米的无痛肿块，临床检查无转移迹象，随后接受了乳房切除术及腋窝淋巴结清扫术。肿瘤未侵犯胸壁和皮肤。肿瘤由丰富的软骨样基质和纤维组织组成，伴有局灶性类骨质基质，被分类为软骨母细胞/纤维母细胞变体。肿瘤具有反向带状模式。肿瘤中央部分的细胞主要为梭形且稀疏，细胞异型性极小，而周边其余肿瘤细胞主要为上皮样、异型且密集。在肿瘤中央部分观察到肿瘤性类骨质编织骨或小梁。腋窝淋巴结未发现转移。在60个月的随访中，患者存活，无局部复发或血行播散迹象。
