Nishio Jun, Ideta Soshi, Iwasaki Hiroshi, Naito Masatoshi
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Oncol Lett. 2013 Sep;6(3):817-820. doi: 10.3892/ol.2013.1455. Epub 2013 Jul 11.
Osteochondrolipoma is an extremely rare histological variant of lipoma with osseous and cartilaginous differentiation. The present study reports an unusual case of an osteochondrolipoma occurring in the left scapular region of a 49-year-old male. The physical examination revealed a 3-cm, hard, non-tender and minimally mobile mass. Plain radiography revealed a faintly ossified soft-tissue mass without evidence of bone erosion. Computed tomography (CT) confirmed the presence of a lesion and the normal appearance of the scapula. Magnetic resonance imaging (MRI) showed a well-circumscribed subcutaneous mass with an almost homogeneous high signal intensity on the T1- and T2-weighted sequences. Contrast-enhanced fat-suppressed T1-weighted sequences demonstrated a faint peripheral and septal enhancement of the mass. A marginal excision of the tumor was performed. Histologically, the tumor was predominantly composed of mature adipocytes mixed with thin trabeculae of mature bone. In addition, small amounts of mature hyaline cartilage and osteoid were identified in the periphery of the lesion. Based on these findings, the tumor was diagnosed as an osteochondrolipoma. The patient demonstrated no evidence of local recurrence within six months of follow-up. Although rare, osteochondrolipoma should be considered as a differential diagnosis of a well-defined, calcified/ossified, subcutaneous mass in the scapular region.
骨软骨脂肪瘤是脂肪瘤一种极为罕见的具有骨和软骨分化的组织学变体。本研究报告了一例发生在一名49岁男性左肩胛区的不寻常骨软骨脂肪瘤病例。体格检查发现一个3厘米大小、质地硬、无压痛且活动度极小的肿块。X线平片显示一个轻度骨化的软组织肿块,无骨质侵蚀迹象。计算机断层扫描(CT)证实了病变的存在以及肩胛骨外观正常。磁共振成像(MRI)显示一个边界清晰的皮下肿块,在T1加权和T2加权序列上几乎呈均匀高信号强度。对比增强脂肪抑制T1加权序列显示肿块周边和分隔有轻度强化。对肿瘤进行了边缘切除。组织学上,肿瘤主要由成熟脂肪细胞混合成熟骨的细小梁组成。此外,在病变周边发现少量成熟透明软骨和类骨质。基于这些发现,该肿瘤被诊断为骨软骨脂肪瘤。患者在随访6个月内未出现局部复发迹象。尽管罕见,但骨软骨脂肪瘤应被视为肩胛区边界清晰、钙化/骨化的皮下肿块的鉴别诊断之一。