Yoshida H, Hoshino M, Haraguchi C, Ogawa Y, Kawai N, Sakurai H, Ishihara Y, Higaki Y, Imamura K
Hinyokika Kiyo. 1985 May;31(5):871-4.
Prostatic tissue levels of Cefoperazone (CPZ) were studied after the administration of 3 g of CPZ, in 16 patients with prostatic hypertrophy who underwent retropubic prostatectomy. The CPZ concentration in the surgical capsule at 60 min. after the administration of CPZ was about 2 times higher than that in the gland. As compared with the histological type of removed gland, the levels in the glandular hyperplasia were slightly higher than that in the fibromuscular and mixed type hyperplasia, but the difference was not statistically significant. CPZ was found to be effective for the treatment of post-operative and bacterial prostatitis, since the CPZ levels of prostatic tissue were considerably high and above the minimal inhibitory concentration level for most bacteria.
对16例行耻骨后前列腺切除术的前列腺增生患者给予3克头孢哌酮（CPZ）后，研究了其前列腺组织中的CPZ水平。CPZ给药后60分钟时，手术包膜中的CPZ浓度约为腺体中的2倍。与切除腺体的组织学类型相比，腺体增生中的CPZ水平略高于纤维肌性和混合型增生中的水平，但差异无统计学意义。由于前列腺组织中的CPZ水平相当高且高于大多数细菌的最低抑菌浓度水平，因此发现CPZ对治疗术后细菌性前列腺炎有效。
