Fukushima S, Miura T, Kondo I, Fujii H, Hirokawa M, Iwasaki A, Ishizuka E, Kitajima N
Hinyokika Kiyo. 1983 Jan;29(1):87-93.
Prostatic tissue levels of Cefoperazone (CPZ) were determined in 34 patients with prostatic hypertrophy after the intravenous administration of 1 g of CPZ. Prostatic tissue levels of CPZ decreased slowly with time and the elimination half-life was 125 to 171 minutes. The CPZ concentration in the surgical capsule was higher than that in the gland. As compared with the minimal inhibitory concentrations of CPZ, the prostatic tissue levels were considered high enough for the treatment of post-prostatectomy and bacterial prostatitis. Neither the pathological type of prostatic hypertrophy, that of infiltrations, nor the weight of the removed tissue was correlated to the tissue levels of CPZ.
对34例前列腺肥大患者静脉注射1克头孢哌酮（CPZ）后，测定其前列腺组织中的CPZ水平。CPZ的前列腺组织水平随时间缓慢下降，消除半衰期为125至171分钟。手术包膜中的CPZ浓度高于腺体中的浓度。与CPZ的最低抑菌浓度相比，前列腺组织水平被认为足以治疗前列腺切除术后感染和细菌性前列腺炎。前列腺肥大的病理类型、浸润类型以及切除组织的重量均与CPZ的组织水平无关。
