脑源性神经营养因子二肽类似物GSB-106在体外实验中的神经保护作用

Neuroprotective effects of dipeptide analogue of brain-derived neurotrophic factor GSB-106 in in vitro experiments.

作者信息

Logvinov I O, Antipova T A, Gudasheva T A, Tarasiuk A V, Antipov P I, Seredenin S B

机构信息

Laboratory for Pharmacology of Neuroprotection, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2013 Jul;155(3):343-5. doi: 10.1007/s10517-013-2149-6.

DOI:10.1007/s10517-013-2149-6

PMID:24137599

Abstract

Dimeric dipeptide GSB-106, a novel structural analogue of neurotrophin BDNF, in doses from 10(-5) to 10(-8) M protected cultured immortalized mouse hippocampal HT-22 neurons from H2O2 or glutamate damage. The neuroprotective effect of GSB-106 was also shown on cultured SH-SY5Y human neuroblastoma cells after treatment with neurotoxin 6-hydroxidopamine. These data attest to functional similarity of GSB-106 and neurotrophin BDNF.

摘要

二聚体二肽GSB - 106是神经营养因子BDNF的一种新型结构类似物，剂量为10(-5)至10(-8) M时，可保护培养的永生化小鼠海马HT - 22神经元免受过氧化氢或谷氨酸损伤。在用神经毒素6 - 羟基多巴胺处理后，GSB - 106对培养的SH - SY5Y人神经母细胞瘤细胞也显示出神经保护作用。这些数据证明了GSB - 106与神经营养因子BDNF在功能上的相似性。