二肽吡拉西坦类似物诺佩普在谷氨酸毒性模型中提高海马HT-22神经元的活力。
Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.
作者信息
Antipova T A, Nikolaev S V, Ostrovskaya P U, Gudasheva T A, Seredenin S B
机构信息
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2016 May;161(1):58-60. doi: 10.1007/s10517-016-3344-z. Epub 2016 Jun 6.
Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.
在永生化小鼠海马HT-22神经元中，体外研究了诺肽普（N-苯基乙酰基 - 脯氨酰甘氨酸乙酯）对暴露于谷氨酸（5 mM）神经毒性作用的神经元活力的影响。在谷氨酸之前或之后添加到培养基中的诺肽普在10-11-10-5 M的浓度范围内提高了神经元的存活率。对先前在培养的皮质和小脑神经元研究中确定的有效诺肽普浓度进行比较表明，海马神经元对诺肽普的保护作用更敏感。
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