Edersheim T G, Thornton Y S, Alonso M L, Kazam E
Am J Perinatol. 1985 Oct;2(4):328-9. doi: 10.1055/s-2007-999982.
Chorionic villus sampling (CVS) is a recent advance in prenatal diagnosis in the first trimester. maternal serum alpha fetoprotein (AFP) screening for neural tube defects is done from 14-17 weeks gestation. Previous studies have shown an elevation of AFP levels following amniocentesis. The aim of this study was to determine the effect of CVS on AFP levels immediately following this procedure. CVS was performed under sonographic guidance on 22 patients between 6 and 12 weeks gestation undergoing elective termination of pregnancy. A Portex catheter was used for obtaining villi. Maternal serum AFP levels were ascertained before and after CVS by radioimmunoassay. In the group of patients 8 weeks or less, no change in AFP levels was seen; in patients greater than 8 weeks gestation, a significant rise in post-biopsy AFP level was noted in 7 of 14 patients. Further studies are planned to clarify the effect of CVS on AFP levels in patients with ongoing pregnancies. Clarification of this issue is important to the role of CVS in prenatal screening.
绒毛取样（CVS）是孕早期产前诊断方面的一项最新进展。孕14至17周时进行母体血清甲胎蛋白（AFP）筛查以检测神经管缺陷。先前的研究表明羊膜穿刺术后AFP水平会升高。本研究的目的是确定绒毛取样术后即刻对AFP水平的影响。对22例妊娠6至12周且接受选择性终止妊娠的患者在超声引导下进行绒毛取样。使用Portex导管获取绒毛。通过放射免疫测定法在绒毛取样前后测定母体血清AFP水平。在妊娠8周及以下的患者组中，未观察到AFP水平变化；在妊娠超过8周的患者中，14例患者中有7例活检后AFP水平显著升高。计划进一步开展研究以阐明绒毛取样对继续妊娠患者AFP水平的影响。明确这一问题对绒毛取样在产前筛查中的作用很重要。
