Guibaud S, Boisson C, Karras M, Thoulon I M
Laboratoire Central, Hôpital de la Croix-Rousse, Lyon.
J Genet Hum. 1989 Sep;37(3):197-202.
To evaluate incidence and severity of feto-maternal transfusion post-chorionic villus sampling (CVS), maternal serum AFP (MSAFP) were determined for 88 patients before and 15 minutes after CVS. To know whether MSAFP elevation could have clinical implications, a questionnaire was sent to the patients researching if they have had haemorrhages, temperature, spontaneous abortion or premature delivery in the period post CVS. Results of the present study indicate that 44.7% of patients present MSAFP significative elevation (greater than or equal to 8 micrograms/l), a variable elevation (from 8 to 423 micrograms/l). There is no relation between MSAFP elevation and unfavourable events post CVS.
为评估绒毛取样（CVS）后母胎输血的发生率和严重程度，对88例患者在CVS前及CVS后15分钟测定母血甲胎蛋白（MSAFP）。为了解MSAFP升高是否具有临床意义，向患者发送了一份问卷，调查他们在CVS后期间是否有出血、体温变化、自然流产或早产情况。本研究结果表明，44.7%的患者出现MSAFP显著升高（大于或等于8微克/升），升高幅度不一（从8至423微克/升）。MSAFP升高与CVS后不良事件之间无关联。
