Department of Anesthesiology, Division of Pain Medicine, University of Texas Medical Branch, Galveston, Texas.
Clin Ther. 2013 Nov;35(11):1721-7. doi: 10.1016/j.clinthera.2013.09.016. Epub 2013 Oct 16.
Vertebral compression fractures caused by osteoporosis are among the most common fractures in the elderly. The treatment focuses on pain control, maintenance of independence, and management of the osteoporosis. Elderly patients often encounter adverse effects to pain medications, do not tolerate bed rest, and are not ideal candidates for invasive spinal reconstructive surgery. Percutaneous vertebral augmentation (vertebroplasty or kyphoplasty) has become popular as a less-invasive alternative. However, studies have questioned the effectiveness of these procedures.
The authors conducted a MEDLINE search using relevant search terms including osteoporosis, osteoporotic vertebral compression fracture, elderly, kyphoplasty and vertebroplasty.
CASE SUMMARY/RESULTS: Two elderly patients presented with a fracture of their third and first lumbar vertebral body, respectively. One patient progressed well with conservative treatment, whereas the other patient was hospitalized secondary to pain after conservative measures failed to offer improvement. The hospitalized patient subsequently opted for a kyphoplasty and was able to resume his normal daily activities after the procedure.
Selecting patients on an individual case-by-case basis can optimize the effectiveness and outcomes of a vertebral augmentation. This process includes the documentation of an osteoporotic vertebral compression fracture with the aide of imaging studies, including the acuity of the fracture as well as the correlation with the physical examination findings. Patients who are functional and improving under a conservative regimen are not candidates for kyphoplasty. However, if the conservative management is not successful after 4 to 6 weeks and the patient is at risk to become bedridden, an augmentation should be considered. A kyphoplasty procedure may be preferred over vertebroplasty, given the lower risk profile and better outcomes regarding spinal alignment.
骨质疏松导致的椎体压缩性骨折是老年人最常见的骨折之一。治疗重点是控制疼痛、保持独立性和治疗骨质疏松症。老年患者经常出现对止痛药的不良反应,不能耐受卧床休息,也不是侵入性脊柱重建手术的理想人选。经皮椎体强化术(椎体成形术或后凸成形术)已成为一种侵袭性较小的替代方法。然而,研究对这些手术的有效性提出了质疑。
作者使用相关搜索词,如骨质疏松症、骨质疏松性椎体压缩性骨折、老年人、后凸成形术和椎体成形术,对 MEDLINE 进行了检索。
病例总结/结果:两名老年患者分别出现第三和第一腰椎椎体骨折。一名患者经保守治疗后病情好转,而另一名患者因保守治疗未能改善疼痛而住院。住院患者随后选择了后凸成形术,术后能够恢复正常的日常活动。
根据具体情况选择患者可以优化椎体强化术的效果和结果。这个过程包括使用影像学研究(包括骨折的急性程度和与体格检查结果的相关性)来记录骨质疏松性椎体压缩性骨折。在保守治疗方案下功能和病情改善的患者不适合进行后凸成形术。然而,如果在 4 至 6 周后保守治疗不成功且患者有卧床不起的风险,则应考虑进行强化治疗。与椎体成形术相比,后凸成形术可能更具优势,因为其风险更低,对脊柱排列的效果更好。