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用于治疗阿尔茨海默病的现有疗法和新兴疗法。

Current and emerging therapies for Alzheimer's disease.

机构信息

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.

出版信息

Clin Ther. 2013 Oct;35(10):1480-9. doi: 10.1016/j.clinthera.2013.09.009.

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, with a rapidly increasing worldwide prevalence. Although no cure for AD has yet been found, substantial progress has been made in our understanding of AD pathogenesis. This progress has led to the development of numerous promising compounds in various stages of clinical testing. In this review, the current pharmacologic treatments for AD are discussed in detail, followed by an overview of the main experimental strategies that will shape AD therapeutics over the next decade.

摘要

阿尔茨海默病(AD)是一种破坏性的神经退行性疾病,在全球的患病率正在迅速增加。虽然目前还没有治愈 AD 的方法,但我们对 AD 发病机制的理解已经取得了实质性的进展。这一进展导致了许多有前途的化合物在不同的临床测试阶段的发展。在这篇综述中,详细讨论了 AD 的当前药物治疗方法,随后概述了将在未来十年塑造 AD 治疗的主要实验策略。

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