Isolation and functional characterization of hemoglobin Casper: beta106(G8) Leu replaced by Pro.
作者信息
Wajcman H, Gacon G, Labie D, Koler R D, Jones R T
出版信息
Biochemistry. 1975 Nov 4;14(22):5017-20. doi: 10.1021/bi00693a036.
PMID:241397
Abstract
Hemoglobin Casper (beta106Leu replaced by Pro) can be separated from hemoglobin (Hb) A by isoelectric focusing on polyacrylamide gel. This abnormal hemoglobin was estimated to be 30% of teh total by both isoelectric focusing and heat lability kinetics. Its oxygen equilibrium curves indicate a high oxygen affinity, low degree of subunit interaction, and a decreased Bohr effect. Mixtures of Hb Casper and Hb A appear to bind oxygen as if no hybrid molecules exist.
摘要
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