Bramann H U, Zidek W, Vetter H
Cardiology. 1985;72 Suppl 1:163-6. doi: 10.1159/000173967.
In 13 patients with pheochromocytoma (in all but 2 cases localization by scintigraphy) investigations using Holter long-term ECG were performed under medication with alpha- and beta-sympathicolytic drugs under bed rest conditions. The incidence of ventricular dysrhythmias hardly exceeded the extent of a normal control group. In 1 case alpha-methyltyrosine caused a first to second degree AV block and beyond this a stable high frequency sinus rate without any adaptation to the environmental requests. In 12 patients the frequency profile showed sudden and inadequate rises of heart rate up to 200% of very short duration, reaching their maximum within about 20 s of the onset of muscular activity. Although less pronounced, these characteristics were still found 1-2 weeks after operation. In our opinion the heart rate profiles described reveal a dysfunction of the entire autonomus nervous system in pheochromocytoma.
对13例嗜铬细胞瘤患者（除2例病例外，其余均通过闪烁扫描定位）在卧床休息状态下使用α和β交感神经阻滞剂进行药物治疗时，采用动态心电图进行了研究。室性心律失常的发生率几乎未超过正常对照组的范围。1例患者使用α-甲基酪氨酸后出现一度至二度房室传导阻滞，除此之外，窦性心律稳定且频率较高，对环境需求无任何适应性变化。12例患者的心率图谱显示，心率突然且不适当升高，最高可达正常心率的200%，持续时间很短，在肌肉活动开始后约20秒内达到峰值。虽然术后1至2周这些特征不太明显，但仍可发现。我们认为，所描述的心率图谱揭示了嗜铬细胞瘤患者整个自主神经系统的功能障碍。
