Bramann H U, Zidek W, Vetter H, Grosse-Heitmeyer W
Z Kardiol. 1985 Jan;74(1):55-9.
Investigations in 13 hospitalized patients with pheochromocytomata showed peculiar characteristics of heart rate variation at rest, when compared with normals. All patients were given alpha- and beta-sympatholytic drugs. In one case alpha-methyl-Tyrosine caused I-II degree AV blocks and a stable high frequency sinus rate without physiological variations. Resting heart rate in pheochromocytoma varied interindividually from 55-105/min, in the absence of clinical attacks of the underlying disease. The frequency profile was characterized in 12 patients by sudden and inadequate rises of heart rate (200%) of short duration, which were often recorded within 20 seconds of the onset of muscular activity. A similar but less pronounced heart rate modulation was found 1-2 weeks after operation in 3 cases. Our observations indicate that the heart rate profile described may be a sensitive parameter of dysfunction of the autonomous nervous system in pheochromocytoma. Whether the heart rate characteristics are of diagnostic value has to be assessed by further studies.
对13例住院嗜铬细胞瘤患者的研究表明，与正常人相比，他们在静息时心率变化具有特殊特征。所有患者均接受了α和β肾上腺素能阻滞剂治疗。在1例患者中，α-甲基酪氨酸导致了Ⅰ-Ⅱ度房室传导阻滞以及稳定的高频窦性心律，且无生理波动。在无基础疾病临床发作的情况下，嗜铬细胞瘤患者的静息心率个体差异较大，为55-105次/分钟。12例患者的心率特征表现为心率突然且不充分地升高（达200%），持续时间短，常在肌肉活动开始后20秒内记录到。3例患者术后1-2周发现了类似但不太明显的心率调节情况。我们的观察表明，所描述的心率特征可能是嗜铬细胞瘤患者自主神经系统功能障碍的一个敏感参数。心率特征是否具有诊断价值有待进一步研究评估。
