Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Thromb Res. 2013;132(6):692-5. doi: 10.1016/j.thromres.2013.09.035. Epub 2013 Sep 29.
Dysregulated platelet-endothelial interaction plays a pivotal role in atherothrombotic events in patients with diabetes mellitus (DM). Immature platelet fraction (IPF) is a hematologic parameter of automated hematologic analyzer and is related to platelet size and cytoplasmic RNA contents. It reflects thrombopoiesis and also is often used as the marker of platelet activity.
We compared peripheral blood IPF, IPF count (IPC), and mean platelet volume (MPV) of DM and metabolic syndrome (MetS) patients with those of healthy controls. The IPF, IPC, MPV, and other blood cell indices were measured.
The DM group had significantly higher IPF (2.20 vs. 1.70%, P=.020), IPC (4.80 vs. 4.60×10(9)/L, P=.043), and MPV (10.35 vs. 10.00fL, P=.012) than the control group. Those markers were also increased in MetS patients, but the differences were not statistically significant. Interestingly, when DM patients were stratified according to glycemic control status (≤6.5% HbA1c vs. 6.6-7.9% HbA1c vs. ≥8% HbA1c), both IPF and IPC were significantly increased in poor glycemic control group (P=.014 and .003). Including various diabetic complications in the analysis, IPF was higher in DM patients complicated by cardiovascular disease than the DM group without cardiovascular disease.
IPF is elevated in patients with diabetes and associated with poor glycemic control and cardiovascular complication.
血小板-内皮相互作用失调在糖尿病（DM）患者的动脉血栓事件中起着关键作用。未成熟血小板分数（IPF）是自动血液分析仪的血液学参数，与血小板大小和细胞质 RNA 含量有关。它反映了血小板生成，也常被用作血小板活性的标志物。
我们比较了 DM 和代谢综合征（MetS）患者与健康对照组的外周血 IPF、IPC 和平均血小板体积（MPV）。测量了 IPF、IPC、MPV 和其他血细胞指数。
DM 组的 IPF（2.20%对 1.70%，P=.020）、IPC（4.80×10(9)/L 对 4.60×10(9)/L，P=.043）和 MPV（10.35fL 对 10.00fL，P=.012）明显高于对照组。MetS 患者的这些标志物也有所增加，但差异无统计学意义。有趣的是，当根据血糖控制情况（HbA1c≤6.5% vs. 6.6-7.9% HbA1c vs. HbA1c≥8%）对 DM 患者进行分层时，较差的血糖控制组的 IPF 和 IPC 均明显增加（P=.014 和.003）。在分析中包括各种糖尿病并发症，并发心血管疾病的 DM 患者的 IPF 高于无心血管疾病的 DM 患者。
IPF 在糖尿病患者中升高，与血糖控制不良和心血管并发症有关。
