Especial considerations for neurotoxicological research.

In recent years, there has been much impetus toward a definition of behavior in terms of underlying biological events. Such correlations have been attempted in several areas ranging from learning and memory to neurological disease. Increased information concerning the relation between behavior and neurobiological mechanisms is especially important in the area of neurotoxicology. It is often abnormal behavior that is a first sign of exposure to a neurotoxic agent and such changes may give clues as to the anatomical or chemical sites of attack on the nervous system. These clues might also lead to the development of a therapeutic treatment as to the development of tests designed to reveal exposure to a toxic agent at levels below those causing gross behavioral change. Unfortunately, there is a relatively small amount of literature reporting on both behavioral and biological disturbances caused by a toxic agent in the same experimental animal. However, a variety of methodological advances combined with a growing interest in neurotoxicology is gradually changing this. Increased information concerning the role of defined nerve pathways and the means of action of their chemical constituents offers an opportunity to bring about a deepening understanding of neurotoxic events. This review will suggest how new pharmacological findings can be applied to neurotoxicology. Examples of human and animal exposure to toxic materials will be used and current problems will be shown to be major determinants of future research directions.