p300 表达对结直肠癌患者预后的影响。

Prognostic impact of p300 expression in patients with colorectal cancer.

机构信息

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

J Surg Oncol. 2013 Nov;108(6):374-7. doi: 10.1002/jso.23405. Epub 2013 Sep 23.

DOI:10.1002/jso.23405

PMID:24142575

Abstract

BACKGROUND

This study evaluated the expression of p300 in colorectal cancer, its relationship with clinicopathological characteristics, and its potential prognostic significance.

METHODS

The expression of p300 was measured using immunohistochemistry in tumors and surrounding normal mucosa from 199 patients with primary colorectal cancer. The patients were followed for a median period of 83 months.

RESULTS

Nuclear p300 expression was significantly associated with histology (P = 0.031) and lymph node involvement (P = 0.019). When the low and high p300 groups were subdivided according to tumor location, the disease-free survival rate differed only for the patients with colon cancer (P = 0.008). In addition, the disease-free survival significantly differed with p300 expression for stage II disease (P = 0.038), but not for stage III disease. Multivariate analysis revealed that lymph node involvement (P = 0.014) and p300 expression (P = 0.032) were independent predictors of overall survival in adenocarcinomas.

CONCLUSION

The overexpression of p300 may be an independent favorable prognostic factor for disease-free survival in patients with colorectal cancer.

摘要

背景

本研究评估了 p300 在结直肠癌中的表达，及其与临床病理特征的关系，以及其潜在的预后意义。

方法

采用免疫组织化学法检测 199 例原发性结直肠癌患者肿瘤及周围正常黏膜中 p300 的表达。对患者进行了中位 83 个月的随访。

结果

核 p300 表达与组织学（P = 0.031）和淋巴结受累（P = 0.019）显著相关。当根据肿瘤位置将低表达和高表达 p300 组进一步细分时，仅结肠癌患者的无病生存率存在差异（P = 0.008）。此外，p300 表达与 II 期疾病的无病生存率显著相关（P = 0.038），但与 III 期疾病无关。多因素分析显示，淋巴结受累（P = 0.014）和 p300 表达（P = 0.032）是结直肠腺癌总生存率的独立预测因素。