Jinan Miltary General Hospital, Shandong Province, China.
Asian Pac J Trop Med. 2013 Dec;6(12):968-71. doi: 10.1016/S1995-7645(13)60173-X.
To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus to provide clinical therapeutic basis for radiation sickness.
Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established. Then, the umbilical cord mesenchymal stem cells were injected into the rats via tail vein. Visual and histopathological changes of the experimental rats were observed.
After the injection, the rats in the prevention group and treatment group had remarkably better survival status than those in the control group. The histological observations revealed that the former also had better intestinal mucosa structure, more regenerative cells and stronger proliferation activity than the latter.
Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.
检测人脐带间充质干细胞对大鼠急性放射性肠炎的治疗效果，为辐射病的临床治疗提供依据。
体外培养人脐带间充质干细胞，建立大鼠急性放射性肠炎模型，经尾静脉注射脐带间充质干细胞，观察实验大鼠的一般情况及组织病理学变化。
预防组和治疗组大鼠的生存状态明显优于对照组，组织学观察发现，预防组和治疗组大鼠的肠黏膜结构更好，再生细胞更多，增殖活性更强。
人脐带间充质干细胞对大鼠急性放射性肠炎有明确的治疗作用。
Zotero 插件