豚鼠中髓鞘碱性蛋白（MBP）诱导的脱髓鞘的剂量依赖性

Dose-dependency of MBP-induced demyelination in the guinea pig.

作者信息

Moore G R, Traugott U, Stone S H, Raine C S

出版信息

J Neurol Sci. 1985 Sep;70(2):197-205. doi: 10.1016/0022-510x(85)90087-5.

Abstract

The pathology of experimental allergic encephalomyelitis (EAE) induced by bovine myelin basic protein (MBP) has been examined in the guinea pig with a series of doses ranging from 37.5 micrograms to 600 micrograms. This was to investigate whether the previously demonstrated lack of demyelinative effect by MBP was dose-related. At all doses tested, MBP induced clinical disease. Inflammation was the major feature of lesions in all animals. However, no demyelination was seen when 75 micrograms MBP or less was given. At higher doses (150 micrograms upwards), MBP always induced intense inflammation but demyelination was encountered inconsistently. These observations support the contention that in addition to an immune response to MBP, other factors contribute to autoimmune demyelination.

摘要

在豚鼠身上，用一系列剂量从37.5微克到600微克的牛髓鞘碱性蛋白（MBP）诱导实验性变应性脑脊髓炎（EAE），并对其病理情况进行了检查。目的是研究先前证明的MBP缺乏脱髓鞘作用是否与剂量相关。在所有测试剂量下，MBP均诱发了临床疾病。炎症是所有动物病变的主要特征。然而，给予75微克或更少的MBP时未观察到脱髓鞘现象。在较高剂量（150微克及以上）时，MBP总是诱发强烈炎症，但脱髓鞘现象并不一致。这些观察结果支持了这样的观点，即除了对MBP的免疫反应外，其他因素也导致自身免疫性脱髓鞘。