使用超极化（83）Kr 的表面四极弛豫（SQUARE）进行肺部 MRI 对比。
Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr.
机构信息
Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham NG7 2RD, UK; School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.
出版信息
Magn Reson Imaging. 2014 Jan;32(1):48-53. doi: 10.1016/j.mri.2013.08.007. Epub 2013 Oct 18.
Hyperpolarized (83)Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the (83)Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched (83)Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized (83)Kr MRI after krypton inhalation. Different (83)Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized (83)Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.
先前已经证明，极化（83）Kr 可使 MRI 对比敏感，适用于多孔模型系统中的表面化学成分。方法学的进步导致（83）Kr 的极化度和产生的信号强度有了实质性的提高。使用改进的方法通过自旋交换光学泵浦对同位素富集（83）Kr 进行极化，对吸入氪气后的离体啮齿动物肺的内部解剖细节进行了高极化（83）Kr MRI 检测。在离体大鼠肺中，主支气管和实质区域之间发现（83）Kr 的弛豫时间不同。T1 加权高极化（83）Kr MRI 首次证明了表面四极弛豫（SQUARE）肺部 MRI 对比。
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