有氧运动对先天免疫反应的脂质效应分子的影响。
Effects of aerobic exercise on lipid-effector molecules of the innate immune response.
机构信息
1Department of Biological Sciences, California State University Los Angeles, Los Angeles, CA; and 2School of Kinesiology and Nutritional Sciences, California State University Los Angeles, Los Angeles, CA.
出版信息
Med Sci Sports Exerc. 2014 Mar;46(3):506-12. doi: 10.1249/MSS.0000000000000137.
INTRODUCTION
Consistent, moderate-to-vigorous-intensity exercise has been associated with a lower risk of upper respiratory tract infection (URI). However, the molecular basis for this apparent protection has not yet been fully resolved. Host-derived lipids such as cholesteryl esters (CE) have emerged as important effector molecules of innate defense against infections. Here, we compared antimicrobial CE in nasal fluid before and after moderate-to-vigorous exercise between active and inactive subjects.
METHODS
Nasal fluid was collected from 14 healthy, recreationally active subjects (32 ± 11 yr, 7 men and 7 women) and 14 healthy, inactive subjects (25 ± 3 yr, 7 men and 7 women) before and after treadmill exercise at 70% heart rate reserve. Nasal fluid was analyzed for lysozyme, cholesteryl linoleate (CL), cholesteryl arachidonate (CA), and albumin (Alb) concentrations.
RESULTS
Baseline concentrations (mean ± SEM, inactive vs active) of lysozyme (117.7 ± 31.1 vs 122.9 ± 15.5 μg·mL), CL + CA (15.3 ± 1.8 vs 26.2 ± 10.05 μg·mL), and Alb (156.6 ± 54.5 vs 126.9 ± 32.8 μg·mL) were similar to previously reported levels and did not differ significantly between study groups. However, postexercise, CL + CA concentration was significantly lower in inactive compared with active subjects (7.8 ± 1.5 vs 20.1 ± 4.8 μg·mL, P = 0.036) dropping below the antimicrobial effective range. Once adjusted to Alb concentrations, the changes were no longer significant, suggesting that plasma transudation accounted for the increased CA + CL concentration postexercise in the active group relative to the inactive group.
CONCLUSIONS
Moderate-to-vigorous aerobic exercise acutely decreases the antimicrobial CE response in inactive subjects but does not modify baseline levels of CE between active and inactive subjects. This suggests that compared with active individuals, inactive individuals may be at greater risk for upper respiratory tract infection immediately postexercise.
简介
一致的、适度到剧烈强度的运动与上呼吸道感染（URI）的风险降低有关。然而，这种明显保护的分子基础尚未完全解决。宿主来源的脂质，如胆固醇酯（CE），已成为对抗感染的固有防御的重要效应分子。在这里，我们比较了活跃和不活跃受试者在适度到剧烈运动前后鼻液中的抗菌 CE。
方法
从 14 名健康的、有规律运动的受试者（32 ± 11 岁，7 名男性和 7 名女性）和 14 名健康的、不活跃的受试者（25 ± 3 岁，7 名男性和 7 名女性）中收集鼻液，然后在跑步机上以 70%的心率储备进行运动前后。分析鼻液中的溶菌酶、胆甾醇亚油酸酯（CL）、胆甾醇花生四烯酸酯（CA）和白蛋白（Alb）浓度。
结果
基础浓度（平均值 ± SEM，不活跃与活跃）的溶菌酶（117.7 ± 31.1 与 122.9 ± 15.5 μg·mL）、CL+CA（15.3 ± 1.8 与 26.2 ± 10.05 μg·mL）和 Alb（156.6 ± 54.5 与 126.9 ± 32.8 μg·mL）与之前报道的水平相似，且两组之间无显著差异。然而，运动后，不活跃组的 CL+CA 浓度明显低于活跃组（7.8 ± 1.5 与 20.1 ± 4.8 μg·mL，P=0.036），降至抗菌有效范围以下。调整 Alb 浓度后，这些变化不再显著，这表明相对于不活跃组，活跃组运动后 CA+CL 浓度的增加是由血浆渗出引起的。
结论
适度到剧烈的有氧运动可使不活跃受试者的抗菌 CE 反应在短期内降低，但不会改变活跃和不活跃受试者之间 CE 的基线水平。这表明与活跃个体相比，不活跃个体在运动后立即患上呼吸道感染的风险可能更高。
Zotero 插件