Geiger S, Czernobilsky B, Marshak G, Geiger B
Oral Surg Oral Med Oral Pathol. 1985 Nov;60(5):517-23. doi: 10.1016/0030-4220(85)90241-5.
A 15-year-old boy was referred to the ear, nose, and throat clinic because of a swelling in the upper premolar region. The initial diagnosis of a poorly differentiated soft-tissue sarcoma was made. Further immunohistochemical studies established a definitive diagnosis of embryonal rhabdomyosarcoma. The tumor cells coexpressed both desmin, the component of muscle type intermediate filaments, and vimentin, which is typically found in mesenchymal tissues. Such coexpression is found in the early stages of myogenic differentiation. Another cytoskeletal protein, actin, was also found in relatively high concentrations. These results suggested the possible use of antibodies to these cytoskeletal proteins as histogenetic markers for the diagnosis of poorly differentiated rhabdomyosarcoma.
一名15岁男孩因上前磨牙区肿胀被转诊至耳鼻喉科诊所。初步诊断为低分化软组织肉瘤。进一步的免疫组织化学研究确诊为胚胎性横纹肌肉瘤。肿瘤细胞同时表达肌动蛋白（肌肉型中间丝的成分）和波形蛋白（通常存在于间充质组织中）。这种共表达在肌源性分化的早期阶段出现。另一种细胞骨架蛋白肌动蛋白也以相对较高的浓度被发现。这些结果表明，针对这些细胞骨架蛋白的抗体可能作为组织发生学标志物用于诊断低分化横纹肌肉瘤。
