Kontos Andreas, Mitry Danny, Althauser Susanne, Jain Saurabh
Department of Ophthalmology, Royal Free Hospital , London , UK.
Cutan Ocul Toxicol. 2014 Sep;33(3):233-4. doi: 10.3109/15569527.2013.835817. Epub 2013 Oct 22.
Acute toxic serous macular detachment after cataract surgery is very rare, and has been described previously with the use of high concentrations of intra-cameral cefuroxime. We report a case of serous macular detachment and cystoid macular edema 1 day after uncomplicated phacoemulsification using standard dose subconjunctival cefuroxime at the end of surgery. Our case demonstrates that subconjunctival cefuroxime may cause retinal toxicity in a similar fashion to intra-cameral cefuroxime, possibly due to entry of the drug into the anterior chamber through the section or trans-scleral absorption. To our knowledge, this is the first report of this complication with subconjunctival administration of cefuroxime.
白内障手术后急性中毒性浆液性黄斑脱离非常罕见，此前曾有使用高浓度前房内头孢呋辛导致该情况的报道。我们报告了1例在手术结束时使用标准剂量结膜下注射头孢呋辛的单纯白内障超声乳化术后1天出现浆液性黄斑脱离和黄斑囊样水肿的病例。我们的病例表明，结膜下注射头孢呋辛可能以与前房内注射头孢呋辛类似的方式引起视网膜毒性，这可能是由于药物通过切口进入前房或经巩膜吸收所致。据我们所知，这是结膜下注射头孢呋辛导致该并发症的首例报道。
