Ophthalmic Surg Lasers Imaging Retina. 2021 Nov;52(11):615-618. doi: 10.3928/23258160-20211027-01. Epub 2021 Nov 1.
Intracameral cefuroxime has been associated with postoperative macular edema and sub-retinal fluid. To date, nearly all published cases are attributed to errors in antibiotic dilution, leading to administration of supratherapeutic doses. We report three cases of postoperative macular edema and subretinal fluid following a standard dose of 1 mg/0.1 mL of cefuroxime at the end of cataract surgery. Distinguishing features of these cases were intraoperative zonular instability and history of vitrectomy. We hypothesize that certain factors may increase the risk of cefuroxime-associated retinal toxicity, including history of vitrectomy, zonular compromise, posterior capsular break, surgery for a secondary intraocular lens, and unicameral state. .
眼内注射头孢呋辛可导致术后黄斑水肿和视网膜下积液。迄今为止，几乎所有已发表的病例都归因于抗生素稀释错误，导致给予超治疗剂量。我们报告了三例白内障手术后标准剂量 1mg/0.1ml 头孢呋辛引起的术后黄斑水肿和视网膜下积液。这些病例的鉴别特征是术中晶状体囊膜不稳定和玻璃体切除术病史。我们假设某些因素可能会增加头孢呋辛相关性视网膜毒性的风险，包括玻璃体切除术病史、晶状体囊膜损伤、后囊膜破裂、用于二次人工晶状体的手术以及单房状态。
