Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong Province 510630, China.
Lipids Health Dis. 2013 Oct 23;12:150. doi: 10.1186/1476-511X-12-150.
NMO and ATM are intertwined both clinically and pathologically. Apolipoprotein (apo) A-I, the main apolipoprotein of HDL, plays an important role in lipid metabolism in the cerebrospinal fluid and is known to suppress pro-inflammatory cytokines generated by activated T cells in some autoimmune diseases as an immune regulator. However, the differences in the levels of serum apoA-I between NMO and ATM patients are unclear.
In the present study, serum apo A-I levels were measured in 53 NMO patients, 45 ATM patients and 49 healthy subjects. We tested serum apoA-I levels in all participants and investigated EDSS scores of patients with NMO and ATM. Statistical analyses were performed by using SPSS statistical software.
We found that serum apoA-I levels in patients with NMO were significantly lower in comparison to those with ATM. We also found that serum levels of apoA-I was lower in male subjects in comparison to the female subjects in all groups although these differences were not statistically significant in patients with NMO or ATM. It is also shown in our study that serum apoA-I levels in patients with NMO were significantly elevated after receiving a high dosage of intravenous corticosteroids over a period of one week. However, we did not find any correlation between the apoA-I levels and disease disability.
From this study, we concluded that serum levels of apoA-I were lower in NMO patients compared to patients with ATM. Serum apoA-I studies might provide some useful clues to differentiate NMO cases from ATM cases.
NM0 和 A TM 在临床和病理上相互交织。载脂蛋白 A-I（apoA-I）是 HDL 的主要载脂蛋白，在脑脊液脂质代谢中发挥重要作用，并且已知作为免疫调节剂抑制某些自身免疫性疾病中由活化的 T 细胞产生的促炎细胞因子。然而，NM0 和 A TM 患者之间血清 apoA-I 水平的差异尚不清楚。
本研究测量了 53 例 NM0 患者、45 例 A TM 患者和 49 例健康对照者的血清 apoA-I 水平。我们检测了所有参与者的血清 apoA-I 水平，并调查了 NM0 和 A TM 患者的 EDSS 评分。采用 SPSS 统计软件进行统计分析。
我们发现 NM0 患者的血清 apoA-I 水平明显低于 A TM 患者。我们还发现，尽管 NM0 或 A TM 患者的差异无统计学意义，但在所有组中，男性的血清 apoA-I 水平均低于女性。我们的研究还表明，NM0 患者在接受一周高剂量静脉皮质类固醇治疗后，血清 apoA-I 水平显著升高。然而，我们没有发现 apoA-I 水平与疾病残疾之间存在任何相关性。
从这项研究中，我们得出结论，NM0 患者的血清 apoA-I 水平低于 A TM 患者。血清 apoA-I 研究可能为区分 NM0 病例和 A TM 病例提供一些有用的线索。
