Li Ying, Wang Honghao, Hu Xueqiang, Peng Fuhua, Yang Yu
Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, 600# Tianhe Road, Guangzhou, Guangdong 510630, China.
Clin Neurol Neurosurg. 2010 Jul;112(6):478-81. doi: 10.1016/j.clineuro.2010.03.017. Epub 2010 Apr 15.
To explore the relationship between serum lipoproteins and clinical presentations of NMO patients. To investigate the differences of serum lipoprotein levels between NMO and MS patients.
Serum lipoprotein levels were measured in 56 NMO patients, 53 MS patients and 54 health subjects. Serum lipoprotein levels in all participants and relevant clinical parameters of NMO patients were investigated. Statistical analyses were performed using the SPSS statistical software.
NMO patients had significantly higher serum cholesterol (TC), triglyceride, low-density lipoprotein cholesterol, apolipoprotein B (apoB), lipoprotein (a) levels and TC/HDL-C, apoB/apoA-1 ratios than health control group. NMO patients had significantly higher serum apoB level and apoB/apoA-1 ratio than MS patients. There was little correlation between serum lipoproteins and NMO presentations.
The elevated lipoprotein levels in NMO patients could be just secondary changes with limited value in clinical prediction. However, elevated apoB level and apoB/apoA-1 ratio in NMO might indicate severer disability and might provide some useful information in the differential diagnosis with MS.
探讨血清脂蛋白与视神经脊髓炎（NMO）患者临床表现之间的关系。研究NMO患者与多发性硬化（MS）患者血清脂蛋白水平的差异。
测定56例NMO患者、53例MS患者和54例健康受试者的血清脂蛋白水平。调查所有参与者的血清脂蛋白水平以及NMO患者的相关临床参数。使用SPSS统计软件进行统计分析。
NMO患者的血清胆固醇（TC）、甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B（apoB）、脂蛋白（a）水平以及TC/HDL-C、apoB/apoA-1比值均显著高于健康对照组。NMO患者的血清apoB水平和apoB/apoA-1比值显著高于MS患者。血清脂蛋白与NMO临床表现之间几乎没有相关性。
NMO患者脂蛋白水平升高可能只是继发性改变，在临床预测中的价值有限。然而，NMO患者apoB水平升高和apoB/apoA-1比值升高可能提示更严重的残疾，并且可能在与MS的鉴别诊断中提供一些有用信息。
